COX-1


Also found in: Dictionary, Thesaurus.
Related to COX-1: Cox-2

COX-1

(kŏks′wŭn′)
n.
One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is present in cells throughout the body and is inhibited by NSAIDs.

COX-1

Cyclooxygenase-1 A constitutive enzyme that converts arachidonic acid into prostaglandins–eg, PGE2, a key player in inflammation; it protects the GI tract, kidneys, and platelets; it is induced by injury
References in periodicals archive ?
As early as 1972, another group of scientists found test-tube evidence that acetaminophen could inhibit COX enzymes--which had yet to be subdivided into COX-1 and COX-2--in brain cells.
Blatteis, a physiologist at the University of Tennessee College of Medicine in Memphis, has been testing the effects of COX-1 and COX-2 inhibitors on prostaglandin production in guinea pigs with fever.
Now, a study in rats shows that a recently developed anti-inflammatory drug, celecoxib, thwarts COX-2 but not COX-1, say scientists at the American Health Foundation, a nonprofit cancer research center in Valhalla, N.