Side effects of COMT inhibitors
include nausea, vomiting, diarrhoea and abdominal pain.
Contract award: Supply of open-house discount contracts for drugs with the drug combination levodopa / decarboxylase inhibitor / comt inhibitors
(levodopa / carbidopa / entacapone) = atc n04ba03.
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
may boost levodopa/carbidopa's effects
The number of subjects receiving COMT inhibitors
concomitant with L-dopa therapy was 12 (52.
Evidence indicates adding COMT inhibitors
to levodopa therapy can reduce the end-of-dose failure patients experience as the effect of levodopa decreases, and also decrease the motor fluctuations (Chan et al.
The claim that this may prevent later motor complications needs to be further substantiated, but there may be a role for early introduction of COMT inhibitors
On the other hand, we found no significant role of COMT inhibitors
in sparing SAM or lowering tHcy in L-dopatreated patients.
The COMT inhibitors
tolcapone and entacapone are other new additions.
11) COMT inhibitors
also increase "on" time and reduce "off" time in patients with motor fluctuations.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors
to carriers of the gene.
(entacapone and tolcapone) prevent the breakdown of dopamine, prolonging the effects of levodopa so that dosages of that drug can be reduced.