COMT inhibitors

COMT inhibitors

Drugs that block catechol-o-methyl transferase, an enzyme that breaks down dopamine. COMT inhibitors include entacapone and tolcapone.
Mentioned in: Parkinson Disease
References in periodicals archive ?
Side effects of COMT inhibitors include nausea, vomiting, diarrhoea and abdominal pain.
Contract award: Supply of open-house discount contracts for drugs with the drug combination levodopa / decarboxylase inhibitor / comt inhibitors (levodopa / carbidopa / entacapone) = atc n04ba03.
Also find individual revenue predictions to 2024 for five therapeutic submarkets at world level: -- Dopaminergic agents -- Dopamine receptor agonists -- COMT inhibitors -- MAO inhibitors -- Treatments with other modes of action (grouped).
To some extent this can be addressed by administering MAO-B or COMT inhibitors as part of therapy.
The claim that this may prevent later motor complications needs to be further substantiated, but there may be a role for early introduction of COMT inhibitors with levodopa.
On the other hand, we found no significant role of COMT inhibitors in sparing SAM or lowering tHcy in L-dopatreated patients.
11) COMT inhibitors also increase "on" time and reduce "off" time in patients with motor fluctuations.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors to carriers of the gene.
our novel series of COMT inhibitors for Parkinson's disease confirms our
There are four different types of drugs - levodopa, dopamine agonists, MAOB inhibitors and COMT inhibitors - and within each class, more than one drug is available.
COMT inhibitors exist, but the one that gets into the brain has been noted for its liver toxicity.