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COMT inhibitors

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COMT inhibitors
Drugs that block catechol-o-methyl transferase, an enzyme that breaks down dopamine. COMT inhibitors include entacapone and tolcapone.
Mentioned in: Parkinson Disease


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11) COMT inhibitors also increase "on" time and reduce "off" time in patients with motor fluctuations.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors to carriers of the gene.
COMT inhibitors exist, but the one that gets into the brain has been noted for its liver toxicity.
 
 
 
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