COMT inhibitors

COMT inhibitors

Drugs that block catechol-o-methyl transferase, an enzyme that breaks down dopamine. COMT inhibitors include entacapone and tolcapone.
Mentioned in: Parkinson Disease
References in periodicals archive ?
Side effects of COMT inhibitors include nausea, vomiting, diarrhoea and abdominal pain.
Contract award: Supply of open-house discount contracts for drugs with the drug combination levodopa / decarboxylase inhibitor / comt inhibitors (levodopa / carbidopa / entacapone) = atc n04ba03.
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.
COMT inhibitors may boost levodopa/carbidopa's effects
Evidence indicates adding COMT inhibitors to levodopa therapy can reduce the end-of-dose failure patients experience as the effect of levodopa decreases, and also decrease the motor fluctuations (Chan et al.
The claim that this may prevent later motor complications needs to be further substantiated, but there may be a role for early introduction of COMT inhibitors with levodopa.
On the other hand, we found no significant role of COMT inhibitors in sparing SAM or lowering tHcy in L-dopatreated patients.
The COMT inhibitors tolcapone and entacapone are other new additions.
11) COMT inhibitors also increase "on" time and reduce "off" time in patients with motor fluctuations.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors to carriers of the gene.
COMT inhibitors (entacapone and tolcapone) prevent the breakdown of dopamine, prolonging the effects of levodopa so that dosages of that drug can be reduced.