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COMT inhibitor

   Also found in: Wikipedia 0.01 sec.
COMT inhibitor
Catechol-o-methyltransferase inhibitor Neurology A drug that enhances the effectiveness of levodopa by blocking COMT, an enzyme that metabolizes levodopa before it reaches the brain; ↑ levodopa bioavailability in the brain results in steady and continuous dopaminergic stimulation, and more consistent and effective symptom relief in Parkinson's disease


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11) Tolcapone, a clinically approved COMT inhibitor for the treatment of PD, assists in managing problematic symptoms through maintenance of dopamine levels.
They believe that one way could be to offer targeted therapies with drugs like COMT inhibitors to carriers of the gene.
COMT inhibitors exist, but the one that gets into the brain has been noted for its liver toxicity.
 
 
 
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