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COMT inhibitor

   Also found in: Wikipedia 0.02 sec.
COMT inhibitor
Catechol-o-methyltransferase inhibitor Neurology A drug that enhances the effectiveness of levodopa by blocking COMT, an enzyme that metabolizes levodopa before it reaches the brain; ↑ levodopa bioavailability in the brain results in steady and continuous dopaminergic stimulation, and more consistent and effective symptom relief in Parkinson's disease


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The Major product segments Analyzed are Anti-Alzheimer's Disease Drugs (Cholinesterase Inhibitors, & NMDARA), and Anti-Parkinson's Disease Drugs (Dopaminergic Agents, Dopamine Agonists, & Other PD Drugs (Include COMT Inhibitors, MOA-B Inhibitors, and Dopamine Amplifiers).
The use of COMT inhibitors is increasing; they currently represent about 10 percent of the market for Parkinson's disease.
 
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