COMT


Also found in: Acronyms.

COMT

COMT

Catechol-O-methyltransferase, an enzyme that breaks down dopamine and l-dopa in the brain and thus reduces the effectiveness of some treatments for Parkinson's disease. Drugs that inhibit COMT improve patient responsiveness to treatment with levodopa, one of the mainstays of treatment for Parkinson's disease.
References in periodicals archive ?
Primers designed from Primer 3 software to amplify all the coding regions of COMT gene (Table II).
Table 1 shows the correlations found between the national mean scores on the Big Five personality traits and the frequencies of the 5-HTTLPR S-allele and COMT 158Met allele in all countries for which data on both variables are available.
Existen estudios que sugieren que el alelo que codifica un COMT de actividad baja (COMT-L) puede ser un marcador susceptible para RCIU (6).
She added: "This is the first study to show that the combined effects of the COMT gene with adolescent cannabis use cause physical changes in the brain regions associated with schizophrenia.
The next morning we visited a bigger dairy - or a 'fruitiere' as it's called, because milk and therefore cheese, is considered a fruit or product of the earth - to see how the enormous wheels of Comt are produced, then routinely rubbed in salt during the ageing process.
A variety of different studies of the effect of the low- and high-activity COMT alleles have shown that the biologic context in which each allele operates determines its ultimate effects on cognition and the risk of schizophrenia.
Entacapone, a COMT enzyme inhibitor used in the treatment of Parkinson's disease, is Orion Pharma's patented molecule discovery, available globally as Comtess and Comtan.
Having less of the chemical, an enzyme called COMT, appears to make a person more anxious and highly strung.
They found a person with less of the enzyme COMT is more anxious or highly strung.
Two SNPs were derived from the catechol-O-methyltransferase gene (COMT 1883C [right arrow] G and COMT 1243G [right arrow] A).
For more information about COMT and COMET's performance and deal structure, please visit Fitch's web site at 'www.
The genes involved were COMT, DRD2, DRD1 and OPRK1.