COMT


Also found in: Acronyms.

COMT

COMT

Catechol-O-methyltransferase, an enzyme that breaks down dopamine and l-dopa in the brain and thus reduces the effectiveness of some treatments for Parkinson's disease. Drugs that inhibit COMT improve patient responsiveness to treatment with levodopa, one of the mainstays of treatment for Parkinson's disease.
References in periodicals archive ?
The COMT gene directs the body to produce two versions of catechol-O-methyltransferase.
She added: "This is the first study to show that the combined effects of the COMT gene with adolescent cannabis use cause physical changes in the brain regions associated with schizophrenia.
Comt is an unpasteurised, cream-colour hard cheese unique to the area.
Schilt and coinvestigators decided to study the effects of COMT gene polymorphisms in their subjects.
IF THEY MEET THE CITERIA IN THE TM, YOU'VE COMT TO THE RIGHT PLACE
our novel series of COMT inhibitors for Parkinson's disease confirms our
Dozens of other studies have reported a lower risk of some cancer (like breast, lung, colon, or stomach) in people who eat more of something (like fruits, vegetables, fish, or green tea), but only if they have one version of a gene (with an alphabet soup of names like GST1, COMT, and XRCC1).
Earlier studies have shown that people with this deletion also lack one copy of the COMT gene, which creates a protein that breaks down dopamine, a neurotransmitter.
There are four different types of drugs - levodopa, dopamine agonists, MAOB inhibitors and COMT inhibitors - and within each class, more than one drug is available.
Entacapone, a COMT enzyme inhibitor used in the treatment of Parkinson's disease, is Orion Pharma's patented molecule discovery, available globally as Comtess and Comtan.
Having less of the chemical, an enzyme called COMT, appears to make a person more anxious and highly strung.