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CNS metastases

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CNS metastases
Central nervous system metastases, see there


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Strategies for management of CNS metastases (beyond surgery and/or palliative radiotherapy) might include other targeted therapies with better blood-brain barrier penetration (see below), intrathecal trastuzumab (for which there are a handful of case reports only) or prophylactic cranial irradiation (for which no data are yet available but investigations are ongoing) [48].
For example, patients with recurrent CNS metastases from breast cancer, CNS lymphoma, or carcinomatous/lymphomatous meningitis can be treated with a high-dose methotrexate regimen.
 
 
 
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