CNS metastases

CNS metastases

Central nervous system metastases, see there.
References in periodicals archive ?
Also, Tagrisso is being investigated in the adjuvant and metastatic first-line settings, including in patients with and without CNS metastases, in leptomeningeal metastases, and
5-7) Stratifying patients with breast cancer and CNS metastases into prognostically significant groups is of potential benefit for purposes of individualized therapy.
In this study, we examined a cohort of surgically managed, pathologically proven, metastatic breast carcinoma to the CNS and analyzed those patients based on their molecular subtypes as well as on several clinicopathologic characteristics and follow-up data, including patient age, breast cancer histologic grade, systemic chemotherapy, adjuvant radiotherapy for primary disease, whole-brain radiotherapy for metastatic disease, CNS chemotherapy, and whether CNS metastases were solitary or multiple.
Cases were evaluated for various demographic and clinicopathologic characteristics (Table 1), including clinical stage at diagnosis of primary breast malignancy; systemic chemotherapy and adjuvant radiotherapy for primary malignancy; age (years) at diagnosis of CNS metastasis; site of CNS metastases, including the presence of multifocal versus solitary CNS involvement; whole-brain radiotherapy and chemotherapy for CNS disease; latency (years) from initial malignant diagnosis to development of CNS metastasis; and survival (months) following CNS metastasis.
However, a recent retrospective analysis of more than 12 000 patients determined that the risk of cerebral hemorrhage is not disproportionately higher in patients with CNS metastases and suggested that the administration of bevacizumab should no longer be contraindicated based solely on the presence of brain metastasis (58).
Burstein reported that about 10% of trastuzumab-treated women with metastatic breast cancer develop isolated CNS metastases.
Burstein analyzed CNS metastases occurring among 523 women with HER-2--overexpressing advanced breast cancer who participated in two clinical trials of trastuzumab.
Burstein reported that roughly 10% of trastuzumab-treated women with metastatic breast cancer develop isolated CNS metastases.
Based upon his analysis of CNS metastases occurring among 523 women with HER-2-overexpressing advanced breast cancer who participated in two clinical trials of trastuzumab, he has concluded that the brain is a relative sanctuary for HER2-positive disease.
For example, patients with recurrent CNS metastases from breast cancer, CNS lymphoma, or carcinomatous/lymphomatous meningitis can be treated with a high-dose methotrexate regimen.
We therefore compared the diagnostic accuracy of the monoclonal TPS and the polyclonal TPA tests in terms of identifying and excluding CNS metastases among breast cancer patients, following recent guidelines for reporting studies of diagnostic accuracy of medical tests (11).
a positive CSF cytology or an autopsy with leptomeningeal carcinomatosis <6 months after a negative CSF cytology); and (c) patients without CNS metastases (i.