CNR2

CNR2

A gene on chromosome 1p36.11 that encodes one of two cannabinoid receptors, which belong to the G protein-coupled receptor family. CNR2 inhibits adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner, and is responsible for cannabinoid-induced CNS effects (e.g., effects on mood and cognition) of marijuana. CNR2 may play a role in the inflammatory response, nociceptive transmission and in bone homeostasis. CNR2 is also a less preferred gene symbol for what is now designated as PCDHA6, see there.
References in periodicals archive ?
It's a very important for the further development of CS-TATI-1 to provoke legislative interest in CS-TATI-1 to ensure federal facilitation of further development of the clinical advancement of research necessary for the commercialization of CNR1 and CNR2 agonists and antagonists of HIV Tat expression inhibitors," said Mariel Selbovitz, MPH.
Data published in March by researchers at the Mount Sinai School of Medicine found that phytocannabinoids inhibit TAT induced migration to TAT via CNR2 signal transduction.
Melamede states, "Cannabis Science is very appreciative of the opportunity to present the clinical premise supporting the development of CS-TATI-1 to address the application of CNR1 and CNR2 agonists and antagonists of HIV Tat expression inhibitors to legislative staffers of ranking Members of Congress directly preceding the opening of the XIX International AIDS Conference," said Dr.