PRKAR1A

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PRKAR1A

A gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.

Molecular pathology
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a  thyroid tumour-specific chimeric oncogene.
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