cytomegalovirus retinitis

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Related to CMV retinitis: Acute Retinal Necrosis


inflammation of the retina.
retinitis circina´ta (circinate retinitis) circinate retinopathy.
cytomegalovirus retinitis opportunistic infection of the retina by cytomegalovirus, seen in immunocompromised patients; symptoms include retinal necrosis and hemorrhage, leading to blindness.
exudative retinitis exudative retinopathy.
retinitis pigmento´sa a group of diseases, frequently hereditary, marked by progressive loss of retinal response (as recorded by the electroretinograph), retinal atrophy, attenuation of retinal vessels, and clumping of the pigment, with contraction of the field of vision. It may be transmitted as a dominant, recessive, or X-linked trait and is sometimes associated with other genetic defects. It may become manifest at the age of two or three years, or it may follow a slow course over a period of years. There is no successful treatment or cure for the condition. Early diagnosis allows the patient to prepare for the eventual loss of vision.
retinitis proli´ferans a condition that may result from intraocular hemorrhage, with neovascularization and the formation of fibrous bands extending into the vitreous from the retina; retinal detachment may result.
suppurative retinitis retinitis due to pyemic infection.

cytomegalovirus retinitis

Ophthalmology CMV infection of the eye, a common opportunistic infection in AIDS, a complication of disseminated CMV infection Clinical Retinal inflammation, blindness Management Antivirals–eg, foscarnet, cidofovir, gancyclovir, systemically and as a ganciclovir implant Prognosis Without treatment, retinal necrosis, vision loss

cytomegalovirus retinitis

Abbreviation: CMV retinitis
The most common eye infection in patients with acquired immunodeficiency syndrome. This opportunistic infection is responsible for visual impairment and blindness if left untreated.
See also: retinitis

retinitis, cytomegalovirus (CMV retinitis) 

A rare, chronic, diffuse infection of the retina caused by the cytomegalovirus (CMV), a member of the herpesvirus group. It affects people with an impaired immune system as a result of either AIDS, organ transplantation or chemotherapy for some malignancies such as leukaemia. The signs are whitish retinal lesions, which look granular (not fluffy, cotton-wool spots). These lesions progress into retinal necrosis with absolute visual field loss in that area. The lesions are usually accompanied by haemorrhages. Eventually the lesions coalesce and involve the entire fundus, resulting in complete visual loss. In the initial phase of the disease most patients are usually asymptomatic while those with symptoms will complain of floaters, blurred vision, photopsia, scotomas, metamorphopsia, etc. In some cases, retinal detachment follows the disease. Treatment with dihydroxy propoxymethyl guanine and ganciclovir produces some regression of the disease. See acquired immuno-deficiency syndrome.
References in periodicals archive ?
The widespread availability of HAART has significantly decreased the rates of opportunistic infections, including CMV retinitis [3].
CMV retinitis, which damages eyesight and can cause blindness, is the most common CMV-related condition in people living with AIDS, affecting between 10 and 25 percent of persons with late-stage AIDS.
CMV retinitis, a serious vision-threatening infection that can lead to permanent blindness, affects up to 46% of all immunocompromised people, including organ transplant recipients and AIDS patients.
Artwork was selected by a jury of respected curators, artists and physicians based on its ability to address, discuss, or represent the artist's understanding of and/or experience with CMV retinitis.
However, not everyone with AIDS and CMV retinitis should take foscarnet, Jabs warns.
In people with AIDS, the most common manifestation of CMV is CMV retinitis, a sight-threatening form of this disease.
Roche scientists presented the AVAC with data from a randomized, controlled study in patients with AIDS and newly diagnosed CMV retinitis which compared the efficacy of valganciclovir and CYTOVENE IV in CMV induction therapy.
CYTOVENE-IV was approved by the FDA in June 1989 as the first drug for the treatment of CMV retinitis in patients with AIDS.
The Committee approved Vitravene(TM) for use in the local treatment of CMV retinitis in newly diagnosed or advanced CMV retinitis when other therapies are considered unsuitable or have been ineffective.
Director of Low Vision Services for Lighthouse International, "People with CMV Retinitis and other HIV/AIDS-related vision disorders can be helped by low vision services.
The Committee recommended that until further experience is gained, Vitravene(TM) be approved for use in the local treatment of CMV retinitis in newly diagnosed or advanced CMV retinitis when other therapies are considered unsuitable or have been ineffective.