ABCC2

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ABCC2

A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC2 is found in the canalicular (apical) part of hepatocytes and involved in biliary transport. Its substrates include chemotherapeutics (e.g., vinblastine) and thus contributes to drug resistance in humans.
 
Molecular pathology
ABCC2 is mutated in patients with Dubin-Johnson syndrome.
References in periodicals archive ?
Having earned his CMRP certification last year, Rader uses his knowledge as a supervisor and engineer to improve oil analysis practices and expand the reliability capabilities from within his manufacturing and energy-focused positions.
These awards allow us to recognize individuals who globally exemplify SMRP's mission of providing industry professionals and practitioners with world-class education and certifications," said Craig Seibold, CMRP, PE, SMRP Chair.
With nearly 4,000 members worldwide, the SMRP community is dedicated to provide a vast array of benefits, including international affiliations, domestic public and private partnerships, educational opportunities, M&R Body of Knowledge resources, the ANSI-accredited CMRP (Certified Maintenance and Reliability Professional) certifications, shared interest groups, and many local and global networking events.
This is a milestone for SMRP, and we are excited to recognize colleagues in the M&R industry who stand out from the crowd - even among a distinguished group like CMRP holders," said SMRP Chair Shon Isenhour, CMRP.
The CMRP of the Year Awards provide a new way to demonstrate the value of our profession and allows colleagues to recognize each other for their work.
SMRP member Bob DiStefano, CMRP and CEO of Management Resources Group, Inc.
The IEEE-IAS/PCA Cement Industry Technical Conference provides a great opportunity for cement manufacturing industry professionals to come together for shared learning and networking," said SMRP member Bob DiStefano, CMRP.
The module introduces an easy, fast, and secure method to help applicants and certificants navigate the process in half the time," said SMRPCO Chair Larry Hoing, CMRP.
The officers-effective October 15-are Chair Shon Isenhour, CMRP, GPAllied; Vice Chair Nick Roberts, CMRP, DuPont; Treasurer Craig Seibold, CMRP, Johns Manville; Secretary Bob Kazar, CMRP, Owens Corning; and Past Chair Stan Moore, CMRP, Carpenter Technology Corporation.
Angela Brito, CMRP, purchasing manager at Hospital for Special Surgery (HSS), will participate in the question-and-answer session after the presentations entitled "GHX Procurement Suite Drives Efficiencies and Savings for HHC and HHS.
Gibbs, CMRP, Logistics and Data Services administrator for WellSpan Health, which was named 2009 GHXcellence U.
Gregg Stepp, CMRP, Director of Supply Chain Operations,