ABCC2

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ABCC2

A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC2 is found in the canalicular (apical) part of hepatocytes and involved in biliary transport. Its substrates include chemotherapeutics (e.g., vinblastine) and thus contributes to drug resistance in humans.
 
Molecular pathology
ABCC2 is mutated in patients with Dubin-Johnson syndrome.
References in periodicals archive ?
La dimension psicosocial estaba compuesta por ocho items en el CMRP.
Caso a opcao seja amostrar 75 plantas, o erro de estimacao seria de [+ or -] 4,49, [+ or -] 5,75, [+ or -] 6,17, [+ or -] 14,33, [+ or -] 10,60 e [+ or -] 14,26% da estimativa da media (m), respectivamente, para os caracteres AP, NRP, CMRP, NFP, NFR e PROD.
Com a retirada do NFR, o NC reduziu para 24 e, assim, as analises de trilha e de regressao linear multipla da produtividade de graos (PROD) em funcao das variaveis explicativas (AP, NRP, CMRP e NFP) podem ser realizadas adequadamente (CRUZ, 2006) (Tabela 3).
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Brian Baird, CMRP, application development and support engineer, North Star BlueScope Steel LLC
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We are thrilled to have SpendAdvisor as a basis to help advocate supply cost reduction," said Adam Wood, CMRP, Interim Director of Purchasing, Hendrick Medical Center.
Keith Ferguson, CMRP, principal, and Kimberly Nilsson, BSN, MBA, senior clinical associate for Premier, will present "OR and Materials Management Working Together to Enhance the OR Supply Chain" on August 16 from 9:30 - 10:45 a.
We are seeing a growing realization among capital-intensive companies that reliability is an important business strategy that improves plant performance and drives financial results," says Terry O'Hanlon, CMRP, publisher and leading reliability expert.