CDK4

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CDK4

A gene on chromosome 12q14 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).

Molecular pathology
CDK4 mutations and those of related proteins (e.g., D-type cyclins, p16(INK4a) and Rb) occur in neoplasia.
References in periodicals archive ?
CMM3 Certification Demonstrates PacificNet's Commitment to Developing
Founder Electronics' ISO9001 and CMM3 certificated Research and Development center has been recognized as China's State Laboratory for Word and Information Processing, as well as the State Engineering Research Center for Electronic Publishing.
Besides this latest award, Langchao was selected earlier as a highest tier (Level A) outsourcing enterprise for the US and European markets by the Ministry of Science and Technology of China and has obtained certifications in ISO9001, ISO14001 and CMM3, while CMMi5 certification has been planned for next year.
E[acute accent]iRobot recently passed its FCS Lead Systems Integrator (LSI) internal CMM level 2 assessment, leading towards an independent CMM3 assessment and certification planned for the end of 2005.
has announced that is has successfully passed the CMM3, CMMI ML3 for SW and SJ/T 11235 certifications, becoming the first company in China's software industry, as well as being the first company in Shanghai, to have passed all these three certifications.