cardiomyopathy, familial hypertrophic, type 7

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cardiomyopathy, familial hypertrophic, type 7

A phenotypically variable hereditary heart disorder (OMIM:613690) characterised by asymmetic ventricular hypertrophy.

Clinical findings
Dyspnoea, syncope, collapse, palpitations, and chest pain triggered by exercise. The disorder has inter- and intrafamilial variability, ranging from benign and asymptomatic to malignant with high risk of cardiac failure and sudden cardiac death.

Molecular pathology
Caused by defects of TNNI3, which encodes type-3 troponin I protein, TnI-cardiac (exclusively expressed in heart muscle).