MMP13

(redirected from CLG3)

MMP13

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 13, which cleaves collagens I in the extracellular matrix. MMP13 may play a role in turnover of articular cartilage.

Molecular pathology
Defects in MMP13 cause spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1. MMP13 may play a role in the pathogenesis of osteoarthritis.