PLA2R1

(redirected from CLEC13C)

PLA2R1

A gene on chromosome 2q23-q24 that encodes a C-type lectin domain protein which acts as a receptor for secretory phospholipase sPLA2-IB, but not for sPLA2-IIA. Binding of sPLA2-IB/PLA2G1B induces different effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, and activation of p38 MAPK to stimulate elastase release and cell adhesion in neutrophils.