CLDN4

CLDN4

A gene on chromosome 7q11.23 that encodes claudin-4, an integral membrane protein of the claudin family, the members of which form part of the tight junction strands and may play a role in embryonic and post-natal organogenesis and function.

Molecular pathology
CLDN4 is deleted in Williams-Beuren syndrome, a multisystem neurodevelopmental disorder.
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References in periodicals archive ?
APOBEC3C is connected to CLDN4 with proteinprotein interaction mediated by SHBG (Warde-Farley et al.
131,132) Other frequently hypomethylated genes, including CLDN4 (chromosome arm 7q, encoding claudin-4), LCN2 (chromosome arm 9q, encoding lipocalin-2), SFN/14-3-3[sigma] (chromosome arm 18q), TFF2 (chromosome arm 21q, encoding trefoil factor 2), MSLN (chromosome arm 16p, encoding mesothelin), and PSCA (chromosome arm 8q, encoding prostate stem cell antigen), are overexpressed in pancreatic cancer cells in comparison with normal pancreatic duct.
42 protein 415 CLDN4 Claudin-4 Hypomethylation 7q11.