CLDN1

CLDN1

A gene on chromosome 3q28-q29 that encodes claudin-1, an integral membrane protein of the claudin family, the members of which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.

Molecular pathology
CLDN1 loss of function mutations cause neonatal ichthyosis-sclerosing cholangitis syndrome.
References in periodicals archive ?
The composition excludes materials that complex with the artichoke leaf extract and the carob fruit extract, and wherein the artichoke leaf extract and the carob fruit extract are present at an amount to provide a synergistic increase in the up-regulation of at least one epidermal-associated gene selected from the group consisting of KRT2, KRT6A, CLDN1, LOR, FLG, IVL, KRT10, AQP3, and KRT14 according to an ex vivo tissue analysis.