CLDN7

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CLDN7

A gene on chromosome 17p13.1 that encodes claudin-7, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
Differential expression of CLDN7 has been described in malignancies of the breast, ovary, liver, urinary tract, prostate, lung, head, neck, thyroid and elsewhere.