CCL18

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CCL18

A gene on chromosome 17q11.2 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL18 is chemotactic for naïve T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. It attracts naïve T cells toward dendritic cells and activated macrophages in lymph nodes, and may play a role in humoral and cell-mediated immune responses.
References in periodicals archive ?
Researchers at the Beatson Institute for Cancer Research in Glasgow discovered that a protein molecule - called Met- Ckb7 - can block reactions to harmless particles like dust mites which the body often mistakes for harmful organisms.
The discovery and description of a potent inhibitor of the CCR3 receptor -- a protein called Met-Chemokine Beta Seven, or CkB7 -- is contained in the newly published manuscript.