CCR5

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CCR5

A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled receptors. CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and RANTES, and transduces a signal by increasing the intracellular calcium ion level. CCR5 may play a role in the control of granulocytic lineage proliferation or differentiation, and is an important co-receptor for macrophage-tropic viruses (e.g., HIV-1) entering host cells.

CCR5

A chemokine receptor; defects in its structure caused by genetic mutation cause the progression of AIDS to be prevented or slowed.
Mentioned in: AIDS
References in periodicals archive ?
People who inherit two copies of the mutant CKR-5 gene, one from each parent, cannot make the protein.
Most people have two normal copies of a gene that directs production of a protein called CKR-5 on the surface of white blood cells.
While it seems reasonable that having mutations in both copies of the CC- CKR-5 gene offers considerable protection from infection with HIV, scientists caution that several HIV strains use molecules other than CC- CKR-5 to infect cells.