KRT5

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KRT5

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that is specifically co-expressed in the basal layer of the epidermis with family member KRT14.

Molecular pathology
KRT5 mutations are associated with epidermolysis bullosa simplex.
References in periodicals archive ?
When gene expression data are compiled from different sources, basal-like tumors in TNBC consistently cluster within a group that express CK5, 6, 14, 17, and caveolin1/2, as well as c-kit and P-cadherin (15,42).
3] % % % 1 2 3 4 5 CK0 1727 14,2 34,8 24,5 CK1 1684 18,5 36,5 31,1 CK2 1701 17,7 35,8 30,2 CK3 1672 18,5 36,9 30,9 CK4 1673 18,6 36,9 31,2 CK5 1672 18,7 36,9 31,3 CK6 1673 18,3 36,9 30,6 Poringumo Sudeties [P.
All immunohistochemical staining was performed at our histology laboratory (The University of Texas Health Science Center at San Antonio Histology Laboratory, San Antonio, Texas) using 2 dual-antibody cocktails for DG3 + CK5/napsin A and p40/ TTF-1 (prediluted; napsin A and p40, rabbit polyclonal; DG3 + CK5 and TTF-1, mouse monoclonal; Biocare Medical, Concord, California).
These, in combination with some of the more traditional markers such as TTF-1, CK5 and p63, may enable much more confident identification of SqCC and LADC.
The chapter on mammospheres and breast carcinomas describes the basal like phenotype of breast CSC with expression of CD44, CK5 and EGFR.
These cadmium-transformed breast epithelial (CTBE) cells displayed characteristics of basal-like breast carcinoma, including ER-(X negativity and HER2 (human epidermal growth factor receptor 2) negativity, reduced expression of BRCA1 (breast cancer susceptibility gene 1), and increased CK5 (cytokeratin 5) and p63 expression.
Powerful 1 GHz PowerPC-based CK5 supports VxWorks(R) and Linux operating systems
The genes EGFR (4 of 23; 17%), Trop2 (2 of 23; 9%), ER-b (1 of 23; 4%), CK5 (1 of 23; 4%); and CEA (0 of 23; 0%) were infrequently expressed in patient samples and were not expressed in the leukocytes.
CK5 helps to define the integrity of the basal cell layer, so the pathologist can confirm the existence of high-grade prostatic intraepithelial neoplasia (HGPIN); even if cancer is not found in the biopsy, ERG positive HGPIN gives strong support for the existence of prostate adenocarcinoma within a few millimeters of the biopsy due to a 'field affect.
Immunohistochemistry studies showed that the lining epithelium was positive for CK7 and focally for CK5 and CK6.
The monoclonal antibody 34[beta]12 targets cytoplasmic highmolecular-weight cytokeratin filaments in basal cells of the benign prostatic glands, namely CK1, CK5, CK10, and CK14.
6,7) The myoepithelial component is highlighted by p63, smooth muscle myosin heavy chains, CK5, CD10, calponin, actin, and S100.