KRT19

(redirected from CK-19)

KRT19

A gene on chromosome 17q21.2 that encodes the smallest of all type-I keratin proteins, which is expressed in the periderm, the transiently superficial layer that surrounds the developing epidermis.
References in periodicals archive ?
By using RT-qPCR, our group has shown that in early breast cancer the detection of peripheral blood CK-19 mRNA-positive cells is an independent prognostic factor for a reduced disease-free interval and overall survival for node-negative breast cancer patients.
Our group has shown that in early breast cancer, the detection of CK-19 mRNA-positive CTCs is an independent prognostic factor both before and after adjuvant chemotherapy.
In patients with early-stage breast cancer, our group has shown that detection of CK-19 mRNA-positive CTCs is an independent prognostic factor, both before and after adjuvant chemotherapy.
Expression of cytokeratin and epithelial membrane antigen has been assessed in various odontogenic lesions, (26,27) and CK-19 has been shown to react with all kinds of odontogenic epithelial cells.
They found that in patients with benign colon diseases, positive events that met the criteria for "tumor cells" were detected with both the CellSearch system and the CK-19 EPISPOT assay, whereas none of these events were found in healthy volunteers.
The EPISPOT (epithelial immunospot) assay can detect tumor-specific proteins, such as full-length CK-19 released by CTCs (6).
Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the light-cycler system.
Detection of CK-19 mRNA-positive cells in the peripheral blood of breast cancer patients with histologically and immunohistochemically negative axillary lymph nodes.
Recent studies of cytokeratin expression in thyroid neoplasms have demonstrated that various low- and high-molecular-weight cytokeratin in general and CK-19 in particular are expressed differentially in PTC.
In addition, immunonegativity for CK-19 in cytology material may be helpful in excluding the diagnosis of PTC.
In another recent study of methods for detecting CTCs, blood samples collected from 76 patients with metastatic breast cancer and from 20 healthy controls were in a direct comparison of 3 techniques: the CellSearch CTC System, the AdnaTest Breast Cancer Select/Detect, and a previously developed real-time RT-qPCR assay for the detection of CK-19 and SCGB2A2 (mammaglobin) transcripts (53).
A highly specific real-time RT-PCR method for the quantitative determination of CK-19 mRNA positive cells in peripheral blood of patients with operable breast cancer.