CITED1

CITED1

A gene on chromosome Xq13.1 that encodes a member of the CITED (CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain) family of proteins. CITED1 may function as a transcriptional coactivator and play a role in melanocyte pigmentation; it is only expressed in melanocytes and the testes.
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Heat-induced antigen retrieval was carried out for CITED1 (pH 6.
Cytokeratin 19 expression was cytoplasmic, CITED1 expression was nuclear and cytoplasmic, and HBME1 expression was membranous, apical, and cytoplasmic (Figure 2, A through D).
Seven of 75 cases were positive for CITED1, which included 4 of 26 follicular adenomas, 2 of 23 goiters and 1 of 7 FTCs.
The cumulative core loss for CK 19, HBME1, and CITED1 was 10% in HD-TMA and 13% in LD-TMA.
CITED1 protein expression suggests papillary thyroid carcinoma in high throughput tissue microarray-based study.
Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma.