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Technological advancement in chromogenic in situ hybridization (CISH) such as higher storage time for analyzed samples for long duration studies is expected to boost penetration of CISH probe in near future.
It seems fitting that CISH, a center with the age-old aim of promoting peace and scholarship, should reside in such an ancient and storied city.
ASI) and Biocare Medical, LLC (Biocare) announced today the signing of a strategic partnership agreement in which Biocare will distribute ASI's IHC and CISH imaging and analysis solution, GenASIs Pathology, in the United States.
CISH encodes a protein that is involved in the immune response to infectious diseases.
Morrison's experience with 652 patients between November 1992 and July 2004 in a rural community setting suggest that CISH is safe and has a short recuperation period with high patient satisfaction.
However, a newly developed ALK CISH, real-time polymerase chain reaction, and ALK protein expression by immunohistochemistry have been also shown to be useful methods for determining ALK gene rearrangement.
CISH has been reported as a potential alternative to FISH, which would permit the use of brightfield microscopy and is more applicable to the typical surgical pathologist's circumstances.
CISH allows detection of gene amplification, chromosome translocations, and chromosome number using conventional enzymatic reactions under the brightlield microscope on FFPE samples.
Large peroxidase-positive intranuclear clusters or >10 individual small signals in >50% of tumor cells (at least 20 cells counted) indicate positive CISH for HER2 amplification.
The SPOT-Lighr[R] HER2 CISH Kit provides the confidence and objectivity of in situ hybridization with the ease of IHC.
The company also provides the SPOT-Light[R] HER2 CISH Kit for assessment of breast cancer patients; the Dynachip[R] System for automated HLA antibody screening; and molecular diagnostic instruments such as the 3500 Dx Series Genetic Analyzer, cleared for diagnostic use in certain European countries, and the 7500 Fast Dx Real-Time PCR instrument.
Silver ISH (SISH) assay technology, a type of CISH, is one of the emerging technologies in the market.
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