SOCS6

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SOCS6

A gene on chromosome 18q21.2 that encodes a protein belonging to the cytokine-induced STAT inhibitor (CIS)—i.e., suppressor of cytokine signalling (SOCS); STAT-induced STAT inhibitor (SSI)—protein family, which are cytokine-inducible (e.g., by CSF2/GM-CSF, erythropoeitin) negative regulators of cytokine signalling.

Molecular pathology
SOCS6 is highly expressed in chronic myeloid leukaemia (CML) and erythroleukaemia.
References in periodicals archive ?
This paper aims to identify and analyze contributions made by the seven innovation activities of CIS4 (Community Innovation Survey), considering the four different innovation typologies: product, process, organizational and marketing in a small open economy (Portugal).
However, other important innovation inputs, such as acquisition of machinery and equipment, acquisition of external knowledge, training, marketing activities and other procedures and technical preparations considered in CIS4 have rarely been explored in innovation studies.
This finding led us to the research question: "Are all the seven innovation activities of CIS4 important to explain propensity to innovate in manufacturing and service sectors in a small open economy?
Robin (2010) Innovation and Productivity: A Firm-Level Analysis for French Manufacturing and Services Using CIS3 and CIS4 Data (1998-2000 and 2002-2004).
The new Construction Industry Scheme (CIS) legislation will come into force on April 6 2006 and will have a significant impact on any construction company which uses CIS4 labour-only subcontractors.
In addition, this will also mean that contractors expecting the Inland Revenue to offset the 18pc deduction made from CIS4 holders against the PAYE liability are in for a nasty shock.
Also, it doesn't matter that an individual holds a CIS4 subcontractor's card, it's a question of whether he or she is really an employee and should therefore be taxed as such.
CIS4 is a critical operational system used by Humberside Police, linking vital information from units responsible for crime, intelligence and domestic violence.
A web-based solution, CIS4 provides police officers with a single real-time system with improved search and information presentation capabilities.
Rather than maintaining a whole series of data in silos, CIS4 links all information to a single entity such as name, location or other information types.
However, it is worth noting that local Inspectors of Taxes are split on the interpretation of what should be 'minor and technical' which could result in a large number of subcontractors being allocated a CIS4 Registration card in one area, while a company with similar criteria but in a different location, being granted a CIS5 or 6 certificate.
If a sub-contractor is downgraded to a CIS4 Registration card, then they only have the option of appeal to the General Commissioners.