BCL10

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BCL10

A gene on chromosome 1p22 that encodes a protein which contains a caspase recruitment domain (CARD); it induces apoptosis, activates NF-kappaB and interacts with other CARD domain proteins (e.g., CARD9, 10, 11 and 14), which are thought to act as upstream regulators in NF-kappaB signalling.

Molecular pathology
BCL10 protein product forms a complex with MALT1, a protein encoded by a gene that is translocated in MALT lymphoma and together activate NF-kappaB; deregulation of either BCL10 or MALT1 may lead to MALToma.
References in periodicals archive ?
today announced that it has received a FDA pre-market clearance letter for the 510(k) it submitted for its improved version of its CIPER Kit.
Then there's the priest at the center of the two cases that fmally brought all of these other horror stories to light last April, when journalist Gustavo Vil-larrubia wrote about them for the Chilean news site CIPER, the Center for Investigative Journalism.
In late April, the online investigative-journalism site CIPER revealed that the INE--a branch of the Ministerio de Economia--may have tweaked the numbers on its most recent national census.