CDKN1A

(redirected from CIP1)
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CDKN1A

A gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.
References in periodicals archive ?
Next, Harper and Elledge determined that in a laboratory dish, CIP1 virtually shut down the chemical activity of the cyclin-dependent kinase.
Enhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1/ CIP1 expression in ulcerative colitis.