DISCREPANCY IN THE PROPORTIONS OF CIMP IN MSI+ CRCS BETWEEN CRCS IN WESTERN AND EASTERN POPULATIONS
For CRCs in Western populations, approximately two-thirds of sporadic MSI+ CRCs are CIMP+, a result that is consistently obtained regardless of which CIMP panel markers and methylation analysis technologies are used.
BRAF MUTATION IS CLOSELY ASSOCIATED WITH CIMP BUT NOT WITH MSI
Although some controversy exists regarding the association of CIMP with KRAS mutations, (32,43) mutations in BRAF have been consistently associated with CIMP.
Microsatellite instability status does not correlate with the frequency of BRAF mutations, although the BRAF mutation is positively correlated with CIMP, independent of MSI status.
CIMP STATUS-RELATED DIFFERENCES IN THE CLINICOPATHOLOGIC FEATURES OF MSI+ CRCS
CIMP+/ MSI+ tumors undergo gene inactivation by CIMP, in addition to those inactivated by MSI, which are shared by both subsets of MSI+ CRCs.