DDX11

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DDX11

A gene on chromosome 12p11 that encodes a putative RNA helicase which contains a conserved Asp-Glu-Ala-Asp (DEAD) motif. RNA helicases are implicated in various processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX11 has both ATPase and DNA helicase activity, and binds to both single- and double-stranded DNA.
References in periodicals archive ?
Debt issuance programme of CHL1,500,000 assigned national scale new rating of 'F2(chl)' and 'BBB+(chl)'.
CHL1 and fls485 are 2 of these genes, which map within or close to the uveal melanoma susceptibility locus UVM2 at 3p25.