FOXN3

(redirected from CHES1)

FOXN3

A gene on chromosome 14q31.3 that encodes a member of the forkhead family of transcription factors, which is thought to suppress cell cycle checkpoint mutations by activating an MEC1-independent checkpoint pathway.
References in periodicals archive ?
25) Deletion of chromosome 14 extending from the q24 to q31 band encompasses additional candidate genes involved in tumorigenesis, including SEL1L (the human ortholog of the C elegans sel-1 suppressor enhancer of lin-12), CHES1 (checkpoint suppressor 1), and MAP3K9 (mitogen activated protein kinase kinase kinase 9) genes.
Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1.