CGRP


Also found in: Acronyms.

CGRP

CALCA

A gene on chromosome 11p15.2 that encodes peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin, by tissue-specific alternative RNA splicing of gene transcripts and cleavage of inactive precursor peptides. Calcitonin regulates calcium and phosphorus metabolism; calcitonin gene-related peptide is a vasodilator; katacalcin is a calcium-lowering peptide.

CGRP

Abbreviation for calcitonin gene-related peptide.
References in periodicals archive ?
Malcolm Weir, Chief Executive Officer of Heptares said, This agreement is an exciting development for our CGRP antagonist program.
Now advancing through the developmental pipeline are three CGRP ligand-neutralizing antibodies and one CGRP receptor antibody.
In addition, the possible mechanisms underlying the gastroprotective effect were explored including the anti-oxidant, anti-inflammatory and anti-apoptotic effects as well as the modulatory effect on CGRP expression.
Moreover, old mice treated with the anti-migraine drug, which inhibits the activity of CGRP receptors, showed a more youthful metabolic profile than untreated old mice.
in-process research and development for the CGRP antibody.
14] Hence, CGRP content of neuronal bodies, including the DRG, can reflect the activity of the C-fibre afferents.
CGRP Duyusal sinirler Keratinosit ve endotel hucre proliferasyonu, Sitokin uretimini uyarma,atopik dermatit Ve numuler ekzemada sinirlerde art?
Vasodilators elevating cAMP levels like CGRP, adenosine and prostacyclin also activate [K.
This ability to inhibit CGRP release to reduce neuronal stimulation has been demonstrated in vitro to occur via binding to the [mu] opioid receptor.
In primary culture of human osteoblast-like cells, CGRP increased cell proliferation, suggesting a role of the peptide in the local regulation of bone formation (Villa et al.
Elevated levels of CGRP suggest neurogenic-related acute inflammation with ensuing vasodilatation as a pathophysiologic mechanism contributing to early symptoms of CRPS I.
Previous studies have suggested that CGRP exacerbates migraine headaches by dilating blood vessels supplying the brain.