cystic-fibrosis-related diabetes

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cystic−fibrosis-related diabetes

Abbreviation: CFRD
DM arising in patients with cystic fibrosis (CF). It is the most common complication of CF other than those conditions that affect the lungs. It is caused by destruction of islet cells (the cells in the pancreas that make insulin) as well as a decrease in sensitivity of the liver and muscles to the actions of insulin. The disease usually first becomes clinically obvious in young adults.

Patient Care

Although CFRD can be diagnosed with fasting glucose blood tests or hemoglobin A1c levels, many experts recommend using an oral glucose tolerance test. Fifteen to thirty percent of patients with CF are affected by their 20th birthday, and perhaps as many as half have the disease by age 30. CFRD is associated with more severe lung disease than is experienced by patients with CF and normal glucose tolerance. Oral hypoglycemic agents, insulin, and exercise are the primary methods of treatment. Caloric restriction, a cornerstone of treatment for other forms of diabetes, is relatively contraindicated because of the need for aggressive nutritional supplementation in CF patients.

See also: diabetes
References in periodicals archive ?
Several factors may account for the lower prevalence of DR in CFRD compared to other forms of diabetes:
While there are no published studies on visual function levels in CFRD subjects, there is substantial evidence that dark adaptation, (99-102) colour vision, (103,104) and contrast sensitivity104 are adversely affected in type 1 and type 2 diabetes, even in the absence of DR.
It is, therefore, important that CF patients are advised to have regular eye examinations, and those with CFRD to attend annual retinal screening.