CES1


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CES1

A gene on chromosome 16q22.2 that encodes a member of the carboxylesterase family, which hydrolyse or transesterify xenobiotics (e.g., cocaine and heroin) and endogenous substrates with ester,
thioester or amide bonds. CES1 may participate in fatty acyl and cholesterol ester metabolism, and may play a role in maintaining the blood-brain barrier. It is the major liver enzyme and functions in liver drug clearance.
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Na segunda avaliacao (dados nao apresentados), as caracteristicas que apresentaram correlacao positiva e altamente significativa com a MSPA, no tratamento a 40% da CC, foram o CES1 (r=0,79) e o NFV (r=0,87) e, a 90% da CC, apenas o CES1 (r=0,71).
1 38 [+ or -] 8 CES1 11 [+ or -] 3 19 [+ or -] 2 CES2 9.
50] (nM) (a) sEH Siduron 33 [+ or -] 3 TCC 13 [+ or -] 1 CES1 Triclosan 210 [+ or -] 20 TPP 43 [+ or -] 3 CES2 Carbophenothion 34 [+ or -] 1 Triclosan 580 [+ or -] 30 TPP 50 [+ or -] 2 CES3 Carbophenothion 110 [+ or -] 15 Parathion 4 9 [+ or -] 0.