FGFR1

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FGFR1

A gene on chromosome 8p12 that encodes fibroblast growth factor receptor-1, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR1 mutations are associated with inherited syndromes (e.g., Antley-Bixler syndrome, autosomal dominant Kallmann syndrome 2, Jackson-Weiss syndrome, osteoglophonic dysplasia and Pfeiffer syndrome), as well as myeloproliferative disorders and stem cell leukaemia lymphoma syndrome.
References in periodicals archive ?
Legal experts of BSP, however, counter that CEK has registered the GERB MPs as an initiative committee backing the "yes" position and now must take them out since currently they are proponents of the "no" one.
Communitek offers a complete real-time reporting and analytics web interface for clients to track the performance of each CEK unit by location.
Since evidence was not presented with the claim, the magistrates requested evidence from CEK and local commissions.
Our cell line is able to remain free of unwanted pathogens, and above all, can out-live and outperform the only other tested cell line that registered any evident influenza virus levels, the CEK.
CEK cells are a primary cell line, typically unable to survive beyond five generations of growth, or 'passages'.
The HAN9000 CEK uses a modular design to accommodate the varying needs of different customers.
Xsilon is offering the HAN9000 CEK to vendors and service providers who are looking to deploy M2M services into the home environment, where existing communications technologies have failed to create a major footprint due to their poor connectivity within domestic premises.
TABLE 1 Career Exploration Knowledge Scale (CEKS) and Career Decision Scale (CDS) Subscale Pretest and Posttest Means and Standard Deviations Treatment Group Test Overall (a) Group A (b) Administration [alpha] M SD M Pretest CEKS (e) .