CEBPA


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CEBPA

A gene on chromosome 19q13.1 that encodes a transcription factor which binds as a homodimer to various promoters and enhancers, and as a heterodimer to CEBP-beta and CEBP-gamma. CEBP-alpha also interacts with CDK2 and CDK4, inhibiting them and causing growth arrest.
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15 Adversity of TET mutation become higher in the presence of FLT3-ITD, NPM1 negative, or poor prognostic genotypes but not in FLT3-ITD negative patients andNPM1 and or CEBPA positive AML.
In addition, CEBPA was not a DEG identified in the IPTP treatment; however, this may be due to the delayed increase in mRNA expression of CEBPA by IPTP treatment, which reached significance only at day 9 (Figure 3).
CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML.
Inherited CEBPA mutations are detected and characterized by a combination of PCR amplification and direct sequencing of the coding and junctional regions of the CEBPA gene.
The clinical significance of mutations in FLT3, NPM1, and CEBPA is well established and included in the 2008 WHO classification of AML.
The CEBPA and PPARG genes are important transcription factors involved in adipogenesis.
The bioinformatic analysis of the APOA2 gene control (upstream) region indicates the potential for a CEBPA [CCAAT/enhancer binding protein (C/EBP) [alpha]] binding site that is not predicted with the minor C allele.