CDX2


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CDX2

A gene on chromosome 13q12.3 that encodes a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates its transcription. CDX regulates the transcription of multiple genes expressed in the intestinal epithelium, both during early differentiation and as part of the maintenance of the intestinal epithelial lining of the small and large intestines.

CDX2

A gut protein used clinically in immunocytochemistry to identify adenocarcinomas of the colon and other tissues and tumors of intestinal origin.
References in periodicals archive ?
Expression and functional role of Cdx2 in intestinal metaplasia of cystitis glandularis.
Conversely, homeobox protein CDX2 expression commonly favors a GI cancer phenotype, as seen in 97% of colorectal cancers, 61% of gastric cancers, and 16% of pancreatic cancers (9), although adenocarcinomas of the ampulla of Vater may also be CDX2-negative (11).
There were no correlations between loss of PTEN expression and the histologic subtype, tumor differentiation, presence of adenomatous component, resection margin status, pT stages, adjuvant therapy status, or expression of cytokeratin (CK) 7, CK20, and CDX2.
factors, including CDX2, as causative in the development or progression of leukemic disease, while absent in the hematopoietic stem and progenitor cells of healthy
OCT4 and CDX2 have an inverse relationship in early embryos, and the expression of CDX2 in pre- and early post-implantation embryos is tightly restricted to the TE lineage (Beck et al.
Microscopically it displays features of single round and cribriform glands floating within mucinous lakes, staining positive for PSA and prostate-specific acid phosphatase and staining negative for CDX2 (marker for intestinal tumours).
One form of ANT is the reversible silencing of Cdx2.
Haplotype analysis revealed the haplotype FtCA (FokI F, TaqI t, VDR-5132 C, Cdx2 A), which contains the TaqI t allele, to be associated with a significantly greater breast cancer risk as compared with the most frequent haplotype FTCG (OR = 1.
The cdx is selected from the cdx family and includes cdx1, cdx2, or cdx4.
Hurlbut and colleagues assume that, unless the CDX2 gene is preemptively silenced, SCNT in humans would produce viable cloned embryos.
Earlier research had shown that a gene known as cdx2 is pivotal in creating tissues that an embryo needs if it's to implant in the womb.