CDKN2B

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
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The methylation changes involved known tumor suppressor or oncogenes genes including CDKN2A, CDKN2B, PTEN and KRAS.
CDKN2B-AS is adjacent to the CDKN2A [cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)] and CDKN2B [cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)] genes, which encode the cyclin-dependent kinase inhibitors.
Although the tumor suppressor genes CDKN2A and CDKN2B are located in this region, the specific gene(s) and/or biological mechanism underlying this risk association is still unknown.
The CDKN2A and CDKN2B genes are cyclin-dependent kinase inhibitors which regulate cell cycle and belong to a family of genes that have been implicated in the pathogenesis of atherosclerosis through their role in transforming growth factor-[beta]-induced growth inhibition.
3 risk-allele locus spans 50-60 kb and is in linkage disequilibrium (LD) with the 3' end of CDKN2B, encoding the cyclin-dependent kinase inhibitor tumor suppressor pl5INK4B, with weaker LD extending through CDKN2B to CDKN2A, which encodes another tumor suppressor pl6INK4B.
3) This region contains the coding sequence for two cyclin-dependent kinase inhibitors, CDKN2A and CDKN2B, which play an important role in the regulation of the cell cycle and have been implicated in the pathogenesis of atherosclerosis, as well as for MTAP, a methylthioadenosine phosphorylase enzyme important in polyamine metabolism and the salvage of adenine and methionine.
80) One of the most common genetic alterations in mesothelioma is the homozygous deletion of the 9p21 locus within a cluster of genes that includes cyclin-dependent kinase inhibitor 2A (CDKN2A), CDKN2B, and methylthioadenosine phosphorylase (MTAP).
EPIGENETIC CHANGES OF CDKN2A & CDKN2B GENES: IMPLICATIONS FOR MYOCARDIAL INFARCTION KIMBERLY HOBBS, UNIV.
The identified region is adjacent to the INK4/ARF locus, which comprises CDKN2A [cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)], CDKN2B [cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)], and CDKN2B-AS [CDKN2B antisense RNA (non-protein coding); previously known as ANRIL (antisense noncoding RNA in the INK4 locus)], a gene encoding a non-protein-coding RNA.
Early and Sustained Response to Azacitidine in High-Risk MDS Patients with Monosomy 7 Correlates with Increased Apoptosis and Not CDKN2B Demethylation Abstract ID: 2530 Kavita K.
43) Methylation of TSG loci APC, CCND2, CDKN2A, CDKN2B, HPPBP1, and RASSF1 was studied in comparison with asbestos exposure.