CDK9


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CDK9

A gene on chromosome 9q34.1 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. CDK9 is part of the multiprotein complex TAK/P-TEFb, an elongation factor for RNA polymerase II-directed transcription, which acts by phosphorylating the C-terminal domain of a subunit of RNA polymerase II. 

Molecular pathology
HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting CDK9 may have a role in AIDS.
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SNS-032 was observed to be a more potent inhibitor of CDK9 and to possess greater pro-apoptotic activity than flavopiridol in human serum.
CDK7 and CDK9 are involved in transcriptional regulation of certain proteins involved in cell survival.
CDK9 and CDK7 additionally play a role in transcriptional regulation, particularly affecting short-half-life proteins including several survival proteins such as MCL-1.
SNS-032 is a novel aminothiazole small molecule cell-cycle modulator that targets CDK2, CDK7 and CDK9, thus halting the uncontrolled cell division characteristic of cancer.
SNS-032 is a novel aminothiazole small molecule cell-cycle modulator that targets the cyclin-dependent kinases CDK2, CDK7 and CDK9, thus halting the uncontrolled cell division characteristic of cancer.