CDK8


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CDK8

A gene on chromosome 13q12 that encodes a cyclin-dependent kinase, which regulates cell cycle progression. CDK8 and its regulatory subunit, cyclin C, belong to the RNA polymerase II holoenzyme complex.
References in periodicals archive ?
3] Human genes: HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; CDKN2C, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; CDK8, cyclin-dependent kinase 8; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF, v-raf murine sarcoma viral oncogene homolog B1.
Through further functional studies, researchers found that eliminating macroH2A led to an increase in CDK8 expression, and the elimination of CDK8 in metastatic melanoma cells impaired their proliferation.
Lead researcher Dr William Hahn, from the Dana-Farber Cancer Institute in Boston, Massachusetts, US, said: "Drugs that target CDK8 may be very useful against tumours whose growth is driven by beta-catenin.