CDK7


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CDK7

A gene on chromosome 5q12.1 that encodes a cyclin-dependent kinase, an important regulator of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1 and is a key component of the transcription factor TFIIH, which is involved in transcription initiation and DNA repair.
References in periodicals archive ?
Aurigene is currently seeking partners for its current pipeline of advanced assets (a) RORg for autoimmune diseases which is in preclinical development (b) Novel NAMPT inhibitors for niche cancers, also in preclinical development (c) Covalent CDK7 and KRAS small molecule programs that are currently in lead optimization.
1] , Gap 0/Gap 1; NPAT, nuclear protein of the ataxia telangiectasia locus; CDK2, cyclin-dependent kinase 2; CDK7, cyclin-dependent kinase 7: akt-1, alpha serine/threonine-protein kinase.
Abstract #0489: "Pharmacokinetic/Pharmacodynamic Correlation with Responses in a Phase 1 Study of Patients with Relapsed/Refractory Acute Leukemias Treated with SNS-595" -- Abstract #0742: "SNS-032 Exhibits Dose-Dependent Mechanism-Based Inhibition of CDK7 and CDK9 in Peripheral Blood Mononuclear Cells from Patients with Advanced Cancers Treated in an Ongoing Phase 1 Trial" About Sunesis' Oncology Programs
The publications, entitled "Neuronal CDK7 in hippocampus is related to aging in Alzheimer's disease" and "Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes," provide a novel mechanistic basis for therapeutic intervention.
CDK7 and CDK9 are involved in transcriptional regulation of certain proteins involved in cell survival.