CDK5


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CDK5

A gene on chromosome 7q36 that encodes a kinase that is involved in controlling the cell cycle by interacting with D1- and D3-type G1 cyclins.
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cerevisiae); PPARG, peroxisome proliferator--activated receptor gamma; AKT2, v-akt murine thymoma viral oncogene homolog 2; INSR, insulin receptor; SLC30A8, solute carrier family 30 (zinc transporter), member 8; HHEX, hematopoietically expressed homeobox; CDKAL1, CDK5 regulatory subunit associated protein 1-like 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDKN2B, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); IGF2BP2, insulin-like growth factor 2 mRNA binding protein 2; FTO, fat mass and obesity associated; JAZF1, JAZF zinc finger 1; CDC123, cell division cycle 123 homolog (S.
CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) was independently identified as anew T2D locus in all 4 studies.
In addition, a locus strongly associated with type 2 diabetes, CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), has clearly been shown to operate through birth weight (31, 32).