CDK4


Also found in: Acronyms.

CDK4

A gene on chromosome 12q14 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).

Molecular pathology
CDK4 mutations and those of related proteins (e.g., D-type cyclins, p16(INK4a) and Rb) occur in neoplasia.
References in periodicals archive ?
Rosamultic acid also induced cell cycle arrest at sub-G1 phase along with downregulation of expression levels of proteins such as CDK4, CDK6 and cyclin D1 which are key controllers of cell cycle.
Derailments of the RB-pathway components, cyclin D1 and cdk4 in particular, seems to participate in the endometrial cancer development in humans.
We hope that these findings will stimulate interest in developing drugs to block CDK4 as a targeted approach to treating this very aggressive cancer," he said.
Objective: This proposal is intended to develop biosensors, named CDKACT and CDKCONF, as smart tools to detect and study key cancer biomarkers, such as CDK4 and CDK5 kinases, which may be of potential value for cancer diagnostic and theragnostic purposes, as well as to propose new selective compounds for cancer therapeutics by screening for non-ATP-competitive inhibitors of these targets.
OncoMap Genes and Mutations (a) Gene Mutations ABL1 16 AKT1 1 AKT2 2 APC 13 BRAF 50 CDK4 1 CDKN2A 11 CSF1R 7 CTNNB1 33 EGFR 51 ERBB2 8 FGFR1 2 FGFR2 6 FGFR3 8 FLT3 9 GNA11 2 GNAQ 3 GNAS 3 HRAS 16 IDH1 3 IDH2 2 JAK2 1 JAK3 3 KIT 27 KRAS 24 MAP2K1 7 MET 6 MLH1 1 MYC 6 NPM1 3 NRAS 22 PDGFRA 20 PIK3CA 23 PIK3R1 14 PTEN 15 RB1 11 RET 14 SRC 1 STK11 12 TP53 7 VHL 7 (a) OncoMap 4 consists of 439 assays designed to interrogate 471 unique mutations in 41 cancer genes.
Fiaschi-Taesch, and the team discovered that combining elevated amounts of the regulatory molecules cdk4 or cdk6 with a variety of D-cyclin proteins, particularly cyclin D3, stimulates human beta cell replication in test tubes.
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ CDK4.
A French study exploring genetic risk factors for melanoma also named CDKN2A as a target gene for susceptibility, along with CDK4 (Biochimie 84[1]:67-74, 2002).
The differential expressions of three targets, namely, ARPC2, CDK4, and GRB-2 were validated by western blot analyses.
16) Abnormal expression of certain other genes, such as the SAS, CDK4, and MDM2 genes, has also been reported in cases of osteosarcomas.
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
PQ relies on the use of potent and selective inhibitors of cellular enzymes called CDK4 and CDK6.