CDK4


Also found in: Acronyms.

CDK4

A gene on chromosome 12q14 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a).

Molecular pathology
CDK4 mutations and those of related proteins (e.g., D-type cyclins, p16(INK4a) and Rb) occur in neoplasia.
References in periodicals archive ?
The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers.
Flavopiridol Induces G1 Arrest with Inhibition of Cyclin- dependent Kinase (CDK) 2 and CDK4 in Human Breast Carcinoma Cells.
Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclindependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.
By contrast, mice expressing a Cdk4 mutation that prevents binding to INK4 inhibitors, show pancreatic hyperplasia due to abnormal [beta]-cell proliferation (9).
The Cyclin-dependent kinase (CDK), including CDK1, CDK2, CDK4 and CDK6, is very important to activate cell cycle (Andrew at al.
During early G1 phase, Cyclin D1 binds to and activates CDK4 and CDK6 kinases, which leads to phosphorylation of Retinoblastoma protein, thus contributing to its inactivation.
It forms complexes with CDK4 or CDK6 and is responsible for the phosphorylation of the retinoblastoma tumour suppressor protein, resulting in the release of E2F transcription factors that allow cell to enter into S phase (4).
Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient.
In contrast, well-differentiated or dedifferentiated liposarcomas display amplifications of chromosome locus 12q13-15, and contain several amplified genes including MDM2, CPM, CDK4, and TSPAN 31.
p16 (INK4a) es una proteina codificada por el gen supresor CDKN2 (MST1, INK4[alpha]) ubicado en el cromosoma 9p21, la cual resulta ser inhibidora de las quinasas dependientes de ciclinas, cdk4 y cdk6, que intervienen en la regulacion de la fase G1 del ciclo celular.
The study found that AHR interacts with other signaling molecules in the cell, CDK4 and CCND1, which could affect the regulation of cell division.