CDK2


Also found in: Acronyms.

CDK2

A gene on chromosome 12q13 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is essential for G1/S phase transition in the cell cycle. CDK2 associates with, and is regulated by, the regulatory subunits of the complex (cyclin A or E), CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B); its activity is regulated by phosphorylation.
References in periodicals archive ?
CDK2, CDK4, p27, and [beta]-actin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
Gene Alteration p53 Overexpression p21WAF1 Overexpression Cyclin D1 High expression Cyclin E High expression Cdk2 High expression Table 2.
In CDK2, a loop of amino acids called the T loop blocks the active site, preventing the kinase from fulfilling its enzymatic duties.
Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.
1% Tween 20, and incubated with primary antibodies: p-MEK1(Ser298), p-MEK1/2(Ser217/221), p-ERK1/2(Thr202/Tyr204), p-AKT(Thr308), p-AKT(Ser473), beta-catenin, cyclin D1 (Cell Signaling Technology), p21, CDK2, p-CDK2 (Bioword, USA), CDK4, CDK6 (Epitomics, USA), cyclin Al, p53 (Millipore, USA), beta-actin (Beijing Biosynthesis Biotechnology, China).
The p21/WAF/Cip protein (p21) binds directly to CDK1, CDK2, and CDK4, and may act as a universal inhibitor of the CDKs' enzyme activity.
1] , Gap 0/Gap 1; NPAT, nuclear protein of the ataxia telangiectasia locus; CDK2, cyclin-dependent kinase 2; CDK7, cyclin-dependent kinase 7: akt-1, alpha serine/threonine-protein kinase.
Martell also served as Director of Oncology Global Clinical Research at Bristol-Myers Squibb Company, where he worked with molecular-targeted drugs in areas such as multi-target kinase inhibitors (including the panHER inhibitor program), CDK2 inhibitor and was closely involved in the Biologic Licensing Application (BLA) for Erbitux, an antibody that targets EGFR.
GGTase I inhibitors block Rho function in cancer cells and induce a G1 phase cell cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb.
Flavopiridol is a potent CDK inhibitor with broad specificity to several kinases including CDK1, CDK2, CDK4, CDK6, CDK8 and CDK9; it arrests the cell cycle at both G1/S and G2/M phases (Senderowicz and Sausville 2000; Schmerwitz et al.