CDK12

CDK12

A gene on chromosome 17q12 that encodes a cyclin-dependent kinase that regulates cell cycle progression and transcription elongation.
References in periodicals archive ?
The genomic landscape of localised prostate cancer has been well defined, describing putative pathogenic BRCA2 germ line mutations as well as somatic and germ line DNA repair alterations found such as BRCA1, CDK12, FANCA, and RAD51B.
Almost all tumors (96%) were characterized by mutations of the gene encoding TP53 in addition to statistically recurrent mutations in nine other loci, including NF1, BRCA1, BRCA2, RBI, and CDK12, although these were of low prevalence.