CDK7

(redirected from CDK-activating kinase)
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CDK7

A gene on chromosome 5q12.1 that encodes a cyclin-dependent kinase, an important regulator of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1 and is a key component of the transcription factor TFIIH, which is involved in transcription initiation and DNA repair.
References in periodicals archive ?
Thrl61 phosphorylation is carried out by CDK-activating kinase (CAK) and occurs in G2 and late M phase, after degradation of cyclin Bl (Hannon et al.
Some CDKs, such as CDK1-CDK4, CDK6 and perhaps CDK11, are involved in progression through the cell cycle, whereas CDK7 has dual roles as a CDK-activating kinase (CAK) and a regulator of the transcriptional machinery.