CDH17

CDH17

A gene on chromosome 8q22.1 that encodes cadherin 17, which is a component of the GI tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of medically important peptide-based drugs. Cadherin 17 may also play a role in the morphological organisation of the liver and intestine.
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In the study by Lin et al, (11) SATB2 and CDH17 were each expressed in 16 of 18 medullary carcinomas of the colon (89%), although most of these cases did not express CK20 and CDX2.
45,46) Also known as liver-intestine cadherin, CDH17 was initially discovered to be a novel calcium-dependent cell adhesion molecule expressed in the liver and intestine of rats.
The authors also summarize the relatively specific markers for differentiating the site of origin of metastatic well-differentiated neuroendocrine tumors, including thyroid transcription factor 1 (TTF-1) for lung; caudal type homeobox 2 (CDX-2) for small intestine and appendix; SATB2 for rectum, colon, and appendix; CDH17 for small intestine, appendix, and rectum; and islet-1 and PAX8 (polyclonal) for pancreas, duodenum, and rectum.
6,7) CDH17 is a novel diagnostic marker for GI tract carcinoma with greater sensitivity than CDX2 in colon cancers.
CDH17 mouse monoclonal (1:4000; clone IH3, Biocare Medical, Concord, California), CK20 (1:10 000; Ks20.
CDH17 Is a More Sensitive Marker for Gastric Adenocarcinoma Than CK20 and CDX2.
While this study did not correlate CDH17 with prognosis or patient survival, it should be noted that other studies (14-16) have shown prognostic value for CDH17 in colon and in gastric adenocarcinoma.
Expression in Normal Tissue Types (n = 26) (a) Tissue Type CDH17 CK20 CDX2 Adrenal gland - - - Appendix + + + Bladder - - - Bone marrow - - - Breast - - - Colon + + + Cervixb - - - Esophagus - - - Heart - - - Kidney - - - Liver - - - Lung - - - Lymph node - - - Ovary - - - Pancreas + - - Pituitary - - - Skeletal muscle - - - Skin - - - Small intestine + + + Smooth muscle - - - Spleen - - - Stomach - + - Testis - - - Tonsil - - - Thymus - - - Uterus - - - Abbreviation: CK, cytokeratin.
Nearly 100% of metastatic colonic ADCs are positive for SATB2, CDH17, and CDX2; however, medullary carcinoma of the large intestine frequently demonstrates loss of expression of both CDX2 and CK20.
60-62) The combined data indicate that positive CDH17 immunoreactivity is most commonly seen in colorectal adenocarcinomas (up to 96%) and a significant portion of gastric, pancreatic, and biliary adenocarcinomas (25%-50%).
In this review article, we (1) propose working algorithms as a standard approach to identifying and classifying undifferentiated neoplasms/tumors of uncertain origin with a focus on carcinomas; (2) review the utilities and pitfalls of frequently used and recently described biomarkers, such as TTF1, napsin A, ER, GATA3, OCT4, SALL4, ARG1, TFF1, CDX2, SATB2, CDH17, and pVHL; (3) refine the most effective IHC panels for the differential diagnosis of carcinomas with different cytokeratin expression profiles ([CK7.
22-25) The main function of CDH17 is to mediate cellcell adhesion and to act as an intestinal peptide transporter.