CDH11


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CDH11

A gene on chromosome 16q21 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH11 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in osteoblastic cell lines. It is upregulated during differentiation, suggesting a role during in bone development and maintenance.

Molecular pathology
Defects in CDH11 commonly occur in aneurysmal bone cysts and consist of a translocation t(16;17)(q22;p13) with USP6.