CDH10

CDH10

A gene on chromosome 5p14.2 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells. CDH10 is a so-called type-II (atypical) cadherin—which lacks a HAV cell adhesion recognition sequence specific to type-I cadherins—and is expressed in the brain and thought to be involved in synaptic adhesions, axon outgrowth and guidance.
References in periodicals archive ?
Reporting online April 28 in the Annals of Human Genetics, the duo confirmed that ASD is strongly associated with genetic variations near CDH9 and CDH10.
London, Apr 29 (ANI): In the world's largest DNA scan for autism, US scientists have uncovered a new gene variant, called CDH10, which is highly common in children suffering from the disorder.
In partnership with 30 research institutions across the US, scientists scrutinized the activity of CDH10 and found that it is most active in key regions that support language, speech and interpreting social behaviour.
The two findings suggest that CDH10 plays a critical role in shaping the developing brain and may contribute to a prenatal risk of autism.
It was found that the variants sat on chromosome 5 between two genes, CDH9 and CDH10.
While CDH9's presence appeared minimal, the scientists discovered that CDH10 was most active in the fetal brain's frontal cortex, a region critical to language, social behaviour and complex thought processes such as judgment.
Our research suggests that CDH10 is switched on at a very early stage and plays an important role in regulating the developing brain.