CDH1


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Related to CDH1: Cadherin 1

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.
References in periodicals archive ?
These data show shared somatic mutations between LCIS and invasive lobular carcinoma, most frequently of CDH1, PIK3CA, and CBFB genes.
Probe and target sequences in CDH1 and RARB are shown in [Table 1].
En el carcinoma hepatocelular se ha demostrado la hipermetilacion del promotor del gen CDH1 y la subsecuente disminucion en el nivel de expresion de la proteina E-cadherina (39).
This irregularity is also apparent when the correlation is analyzed between CDH1 mRNA and 2 mRNAs specifying proteins CTNNB1 and MAX, previously reported as being associated with CDH1 (26, 27).
5) Highly penetrant genetic mutations in TP53 (Li-Fraumeni syndrome), PTEN (Cowden syndrome), CDH1 (Hereditary Diffuse Gastric Cancer syndrome), and STK11 (Peutz Jeghers syndrome) have long been recognized as possible causes of hereditary breast cancer, and now panel testing includes these along with moderately penetrant genes such as checkpoint kinase 2 (CHEK2), ATM serine/ thereonine kinase (ATM), and partner and localizer of BRCA2 (PALB2).
Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome.
O dano funcional da E-caderina pode ocorrer por varios mecanismos, mas frequentemente a delecao ou mutacao do gene CDH1 estao envolvidos.
For persons with two or more cases of diffuse type gastric cancer in first and second degree relatives with one occuring before 50 years of age, or three or more cases occurring at any age, genetic testing for the CDH1 mutation is recommended, along with serial endoscopy with multiple biopsies.
p14, p15, p16, Rb, DAPK; DNA repair genes MGMT, hMLH1; adhesion and metastasis genes CDH1, CDH13; biotransformation genes GSTP1 and signal transduction genes RAR[beta], APC (34).
Four genes namely LAMB1, CDH1, CDH3 and HNF4A play vital roles in keeping the intestine lining healthy.
Con respecto al cancer de tipo heredofamiliar, son identificables, en caso de cancer de mama, las mutaciones en los genes supresores tumorales BRCA1 y BRCA2 (25), asi como en el cancer gastrico lo son las mutaciones en el gen CDH1 (26).