corneal dystrophy of Bowman layer, type 1

(redirected from CDB1)

corneal dystrophy of Bowman layer, type 1

An autosomal dominant (OMIM:608470) form of corneal dystrophy characterised by dusty corneal opacities and a rough, map-like surface with a peripheral condensation ring separated from the limbus by a narrow strip of normal cornea.

Molecular pathology
Has been linked to defects of TGFBI, which encodes an RGD protein that binds to type-I, -II and -IV collagens and plays a role in cell–collagen interactions.
References in periodicals archive ?
5 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, in first- and second-line treatment of Clostridium difficile infection (CDI), nearly 70 percent of surveyed infectious disease specialists and internists will use Optimer's fidaxomicin and nearly half will use Medarex/Merck's CDA1 and CDB1, one year after the launch of these agents.
Progenics' humanized antibodies were tested alongside the parent murine antitoxin antibodies and alongside active comparator antitoxin antibodies, CDA1 and CDB1.