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Related to CD95: Fas protein, Fas ligand


a type I transmembrane protein present on T cells and myeloid cells that may induce apoptosis.


A gene on chromosome 10q24.1 that encodes a member of the TNF-receptor superfamily which is a receptor for TNFSF6/FASLG. FAS contains a so-called death domain, and plays a central role in regulating apoptosis. Ligand binding to FAS results in the formation of a death-inducing signalling complex, comprised of Fas-associated death domain protein (FADD), caspase 8 and caspase 10.

Molecular pathology
FAS has been implicated in the pathogenesis of cancer and immune diseases.
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Dr Allan added: "By testing for the risk variant of the CD95 gene, we should now be able to help doctors identify those vulnerable patients at high risk of either not responding to chemotherapy or developing potentially fatal side effects from their treatment.
The CD95 gene dictates the sending out of 'death signals' to malignant cells, so when these signals are reduced, leukaemia cells do not die and continue to multiply in the blood.
CD3 PerCp-con jugated antibody, CD95 FITC-conjugated, CD95L Biotin-conjugated and Streptavidin phycoerythrin (PE)-conjugated were purchased from Becton Dickinson Co.
APG101 is the most advanced inhibitor of the CD95 ligand (CD95L) that is currently being developed, the company said.
FAS encodes for CD95, a molecule critically involved in the programmed death of some white blood cells.
RBAC treatment had no effect on the level of CD95, but it caused downregulation of Bcl-2 expression.
These proteins may upregulate CD95 (Fas) and Fas L levels and thereby enhancing the susceptibility to Fas mediated killing.
O receptor TNFR1 e similar (APO-1/Fas) ao receptor CD95, que apresenta uma sequencia 80 aminoacidos, quando presente na regiao intracelular e referida como "dominio da morte", esta regiao e responsavel pela transmissao do sinal de inducao da citocina TNF-[alpha].
It is well established that [beta]-amyloid induces apoptosis via mechanisms involving the JNK pathway, induction of CD95 ligand, and the release of Smac via AP-1/Bim activation from mitochondria (34, 35).