CD88

CD88

a type III transmembrane protein present on neutrophils, macrophages, eosinophils, mast cells, and smooth muscle cells; helps trigger chemotaxis and aids in cellular activation, respiratory burst, and degranulation; expressed in monocytoid tumors.
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Interestingly, while toddaculin at 250 [micro]M was able to induce apoptosis in U-937 cells, involving decreased phosphorytation levels of ERIC and Akt, 50 [micro]M toddaculin exerted differentiating effects, inducing both the capacity of U-937 cells to reduce NBT and the expression of differentiation markers CD88 and CD11 b, but no change in p-Akt or p-ERK levels.
In this regard, at higher concentrations toddaculin (6) induced U-937 cell death mediated by caspase cascade activation and down-regulation of ERK 1/2 and serine/threonine protein kinase Akt phosphorylation, whereas at lower concentrations it induced NBT reduction and expression of CD1lb and CD88 monocytic differentiation markers.
Determination of CD88 expression, NBT reduction capacity and chernotactic response